Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary artery
pressures (PAP) and pulmonary vascular resistance (PVR). Optimizing treatment strategies
and timing for transplant remains challenging. Thus, a quantitative measure to predict
disease progression would be greatly beneficial in treatment planning. We devised a novel
method to assess right ventricular (RV) stroke work (RVSW) as a potential biomarker of the
failing heart that correlates with clinical worsening. Pediatric patients with idiopathic PAH or …

Introduction: Pulmonary arterial hypertension (PAH) is characterized by elevated pulmonary
artery pressures and pulmonary vascular resistance. As no definitive treatment options exist,
and lung transplant also carries significant mortality rates, optimizing treatment strategies
and timing for transplant remains crucial; a quantitative measure to predict disease
progression would be greatly beneficial in treatment planning. Hypothesis: We hypothesize
that right ventricular (RV) stroke work correlates with clinical worsening in PAH patients …