Robust and flexible free-standing polymer films for unidirectional drug delivery are
fabricated by sandwiching drug-containing polyelectrolyte multilayer films between poly
(lactic-co-glycolic acid)(PLGA) barrier and capping layers. The drug-containing films are
fabricated by layer-by-layer (LbL) assembly of chemically cross-linked poly (allylamine
hydrochloride)–dextran (PAH-D) microgel and hyaluronic acid (HA), which can load
negatively charged cancer-inhibiting drug, methotrexate (MTX). Because the PLGA barrier …