Robust optimization for intensity modulated proton therapy to redistribute high linear energy transfer from nearby critical organs to tumors in head and neck cancer
Purpose We propose linear energy transfer (LET)-guided robust optimization in intensity
modulated proton therapy for head and neck cancer. This method simultaneously considers
LET and physical dose distributions of tumors and organs at risk (OARs) with uncertainties.
Methods and Materials Fourteen patients with head and neck cancer were included in this
retrospective study. Cord, brain stem, brain, and oral cavity were considered. Two
algorithms, voxel-wise worst-case robust optimization and LET-guided robust optimization …
modulated proton therapy for head and neck cancer. This method simultaneously considers
LET and physical dose distributions of tumors and organs at risk (OARs) with uncertainties.
Methods and Materials Fourteen patients with head and neck cancer were included in this
retrospective study. Cord, brain stem, brain, and oral cavity were considered. Two
algorithms, voxel-wise worst-case robust optimization and LET-guided robust optimization …
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