Rod-like microglia are restricted to eyes with laser-induced ocular hypertension but absent from the microglial changes in the contralateral untreated eye
In the mouse model of unilateral laser-induced ocular hypertension (OHT) the microglia in
both the treated and the normotensive untreated contralateral eye have morphological signs
of activation and up-regulation of MHC-II expression in comparison with naïve. In the brain,
rod-like microglia align to less-injured neurons in an effort to limit damage. We investigate
whether: i) microglial activation is secondary to laser injury or to a higher IOP and; ii) the
presence of rod-like microglia is related to OHT. Three groups of mice were used: age …
both the treated and the normotensive untreated contralateral eye have morphological signs
of activation and up-regulation of MHC-II expression in comparison with naïve. In the brain,
rod-like microglia align to less-injured neurons in an effort to limit damage. We investigate
whether: i) microglial activation is secondary to laser injury or to a higher IOP and; ii) the
presence of rod-like microglia is related to OHT. Three groups of mice were used: age …
Rod-Like Microglia Are Restricted to Eyes with Laser-Induced Ocular Hypertension but Absent from the Microglial Changes in the Contralateral Untreated Eye
MR Hoz Montañana, BI Gallego Collado… - 2013 - docta.ucm.es
In the mouse model of unilateral laser-induced ocular hypertension (OHT) the microglia in
both the treated and the normotensive untreated contralateral eye have morphological signs
of activation and up-regulation of MHC-II expression in comparison with naïve. In the brain,
rod-like microglia align to less-injured neurons in an effort to limit damage. We investigate
whether: i) microglial activation is secondary to laser injury or to a higher IOP and; ii) the
presence of rod-like microglia is related to OHT. Three groups of mice were used: age …
both the treated and the normotensive untreated contralateral eye have morphological signs
of activation and up-regulation of MHC-II expression in comparison with naïve. In the brain,
rod-like microglia align to less-injured neurons in an effort to limit damage. We investigate
whether: i) microglial activation is secondary to laser injury or to a higher IOP and; ii) the
presence of rod-like microglia is related to OHT. Three groups of mice were used: age …
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