G protein-coupled receptor kinases (GRKs) are emerging as important integrative nodes in
cell migration processes. Recent evidence links GRKs (particularly the GRK2 isoform) to the
complex modulation of diverse aspects of cell motility. In addition to its well-established role
in the desensitization of G protein-coupled receptors involved in chemotaxis, GRK2 can play
an effector role in the organization of actin and microtubule networks and in adhesion
dynamics, by means of novel substrates and transient interacting partners, such as the GIT1 …

ABSTRACT G-protein-coupled receptor kinases (GRKs) are a family of serine/threonine
protein kinases. The investigators pay much attention to the roles of GRKs in the signal
transduction through G-protein-coupled receptors (GPCRs) with arrestin ever since a long
time ago. Due to the physiological and pathological observations with the methods of
deletion or overexpression, GRKs are considered as new drug targets. The kinases play a
role in the pathogenesis of hypertension and cell migration through GPCRs and Hedgehog …