Role of WWOX and NF-κB in lung cancer progression
It is generally agreed that the pro-inflammatory, pro-survival transcription factor NF-κB is a
tumor promoter. Tumor necrosis factor alpha (TNF-α or TNF) mediates NF-κB activation.
Tumor suppressor WWOX (FOR or WOX1) is a downstream effector of the TNF signaling.
Thus, activation of both WWOX (FOR or WOX1) and NF-κB may occur during TNF signaling
and/or under stress conditions. Indeed, the first WW domain of WWOX induces the activation
of NF-κB-responsive promoter without TNF participation. It appears that WWOX counteracts …
tumor promoter. Tumor necrosis factor alpha (TNF-α or TNF) mediates NF-κB activation.
Tumor suppressor WWOX (FOR or WOX1) is a downstream effector of the TNF signaling.
Thus, activation of both WWOX (FOR or WOX1) and NF-κB may occur during TNF signaling
and/or under stress conditions. Indeed, the first WW domain of WWOX induces the activation
of NF-κB-responsive promoter without TNF participation. It appears that WWOX counteracts …
Role of WWOX and NF‐κB in lung cancer progression (1049.2)
NS Chang - The FASEB Journal, 2014 - Wiley Online Library
The pro‐inflammatory, pro‐survival transcription factor NF‐κB is considered as a tumor
promoter. Tumor necrosis factor alpha (TNF‐α or TNF) mediates NF‐κB activation. Tumor
suppressor WWOX (FOR or WOX1) is a downstream effector of the TNF signaling. Thus,
activation of both WWOX (FOR or WOX1) and NF‐κB may occur during TNF signaling and/or
under stress conditions. Indeed, the first WW domain of WWOX induces the activation of NF‐
κB‐responsive promoter without TNF participation. It appears that WWOX counteracts with …
promoter. Tumor necrosis factor alpha (TNF‐α or TNF) mediates NF‐κB activation. Tumor
suppressor WWOX (FOR or WOX1) is a downstream effector of the TNF signaling. Thus,
activation of both WWOX (FOR or WOX1) and NF‐κB may occur during TNF signaling and/or
under stress conditions. Indeed, the first WW domain of WWOX induces the activation of NF‐
κB‐responsive promoter without TNF participation. It appears that WWOX counteracts with …
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