Role of Wnt3a in the pathogenesis of cancer, current status and prospective
M Pashirzad, H Fiuji, M Khazei… - Molecular Biology …, 2019 - Springer
Molecular Biology Reports, 2019•Springer
The Wnt signaling pathway plays a critical role in initiation, progression, invasion and
metastasis of cancer. Wnt3a as a canonical Wnt ligand is strongly implicated in the etiology
and pathology of a number of diseases including cancer. Depending on cancer type, Wnt3a
enhances or suppresses metastasis, cell proliferation and apoptosis of cancer cells. This
review summarizes the role of Wnt3a in the pathogenesis of different cancers including
colorectal, prostate, hepatocellular, lung and leukemia, for promoting greater understanding …
metastasis of cancer. Wnt3a as a canonical Wnt ligand is strongly implicated in the etiology
and pathology of a number of diseases including cancer. Depending on cancer type, Wnt3a
enhances or suppresses metastasis, cell proliferation and apoptosis of cancer cells. This
review summarizes the role of Wnt3a in the pathogenesis of different cancers including
colorectal, prostate, hepatocellular, lung and leukemia, for promoting greater understanding …
Abstract
The Wnt signaling pathway plays a critical role in initiation, progression, invasion and metastasis of cancer. Wnt3a as a canonical Wnt ligand is strongly implicated in the etiology and pathology of a number of diseases including cancer. Depending on cancer type, Wnt3a enhances or suppresses metastasis, cell proliferation and apoptosis of cancer cells. This review summarizes the role of Wnt3a in the pathogenesis of different cancers including colorectal, prostate, hepatocellular, lung and leukemia, for promoting greater understanding and clinical management of these diseases.
Springer
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