Role of activated nuclear factor‐κB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck
CT Allen, JL Ricker, Z Chen… - Head & Neck: Journal …, 2007 - Wiley Online Library
CT Allen, JL Ricker, Z Chen, C Van Waes
Head & Neck: Journal for the Sciences and Specialties of the Head …, 2007•Wiley Online LibraryBackground: Nuclear factor‐κB (NF‐κB), a transcription factor known to modulate expression
of factors involved in inflammation, immunity, proliferation, and apoptosis, is constitutively
activated and plays a role in pathogenesis and therapeutic resistance in head and neck
squamous cell carcinoma (HNSCC). Understanding the molecular alterations leading to
aberrant NF‐κB activation in HNSCC may direct investigators to novel therapeutic targets.
Methods: Results of laboratory and clinical studies are reviewed. Results: The structure …
of factors involved in inflammation, immunity, proliferation, and apoptosis, is constitutively
activated and plays a role in pathogenesis and therapeutic resistance in head and neck
squamous cell carcinoma (HNSCC). Understanding the molecular alterations leading to
aberrant NF‐κB activation in HNSCC may direct investigators to novel therapeutic targets.
Methods: Results of laboratory and clinical studies are reviewed. Results: The structure …
Background
Nuclear factor‐κB (NF‐κB), a transcription factor known to modulate expression of factors involved in inflammation, immunity, proliferation, and apoptosis, is constitutively activated and plays a role in pathogenesis and therapeutic resistance in head and neck squamous cell carcinoma (HNSCC). Understanding the molecular alterations leading to aberrant NF‐κB activation in HNSCC may direct investigators to novel therapeutic targets.
Methods
Results of laboratory and clinical studies are reviewed.
Results
The structure, function, and activation of NF‐κB, products of NF‐κB target genes and their role in HNSCC oncogenesis, and current NF‐κB modulating interventions are described.
Conclusions
Aberrant NF‐κB activation contributes to the expression of oncogenes and the malignant phenotype observed in HNSCC. NF‐κB, along with providing a link between cancer and inflammation, may serve as an appropriate therapeutic target to inhibit tumor growth and sensitize cancer cells to established cytotoxic anticancer therapies. © 2007 Wiley Periodicals, Inc. Head Neck, 2007
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