[HTML][HTML] Role of cyclic nucleotides in fetal hemoglobin induction in cultured CD34+ cells
JR Keefer, TA Schneidereith, A Mays, SH Purvis… - Experimental …, 2006 - Elsevier
OBJECTIVE: In vivo, several drugs have been shown to increase fetal hemoglobin (HbF),
including 5-azacytidine (AZA), sodium butyrate (SB), and hydroxyurea (HU). Studies in K562
cells suggest that cyclic guanosine monophosphate (cGMP) is required for HbF induction;
however, the role of cyclic nucleotides in HbF induction in primary erythroid cultures has not
been established. METHODS: CD34-selected peripheral blood monocytes cultured in a
semi-solid serum-free system that mimics in vivo F-cell production are utilized to explore the …
including 5-azacytidine (AZA), sodium butyrate (SB), and hydroxyurea (HU). Studies in K562
cells suggest that cyclic guanosine monophosphate (cGMP) is required for HbF induction;
however, the role of cyclic nucleotides in HbF induction in primary erythroid cultures has not
been established. METHODS: CD34-selected peripheral blood monocytes cultured in a
semi-solid serum-free system that mimics in vivo F-cell production are utilized to explore the …
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