Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model
M Dacheux, S Chaouch, A Joy, A Labat, C Payré… - Biochimie, 2021 - Elsevier
We previously showed that injection of recombinant human group IIA secreted
phospholipase A 2 (hGIIA sPLA 2) to Plasmodium chabaudi-infected mice lowers
parasitaemia by 20%. Here, we show that transgenic (TG) mice overexpressing hGIIA sPLA
2 have a peak of parasitaemia about 30% lower than WT littermates. During infection, levels
of circulating sPLA 2, enzymatic activity and plasma lipid peroxidation were maximal at day-
14, the peak of parasitaemia. Levels of hGIIA mRNA increased in liver but not in spleen and …
phospholipase A 2 (hGIIA sPLA 2) to Plasmodium chabaudi-infected mice lowers
parasitaemia by 20%. Here, we show that transgenic (TG) mice overexpressing hGIIA sPLA
2 have a peak of parasitaemia about 30% lower than WT littermates. During infection, levels
of circulating sPLA 2, enzymatic activity and plasma lipid peroxidation were maximal at day-
14, the peak of parasitaemia. Levels of hGIIA mRNA increased in liver but not in spleen and …
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