Role of neutrophil elastase in stress-induced gastric mucosal injury in rats
W Liu, K Okajima, K Murakami, N Harada… - Journal of Laboratory …, 1998 - Elsevier
Activated neutrophils play an important role in tissue injury by releasing various
inflammatory mediators capable of damaging endothelial cells. To investigate whether
neutrophil elastase (NE) is involved in stress-induced gastric mucosal injury, we examined
the effects of 2 NE inhibitors (ONO-5046 and L-658 758) as well as nitrogen mustard-
induced leukocytopenia on the formation of gastric mucosal lesions, gastric mucosal blood
flow, gastric mucosal microvascular permeability, and gastric neutrophil accumulation in rats …
inflammatory mediators capable of damaging endothelial cells. To investigate whether
neutrophil elastase (NE) is involved in stress-induced gastric mucosal injury, we examined
the effects of 2 NE inhibitors (ONO-5046 and L-658 758) as well as nitrogen mustard-
induced leukocytopenia on the formation of gastric mucosal lesions, gastric mucosal blood
flow, gastric mucosal microvascular permeability, and gastric neutrophil accumulation in rats …
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