Role of poly (ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents
Reactive oxygen and nitrogen species are overproduced in the cardiovascular system
during circulatory shock. Oxidant-induced cell injury involves the activation of poly (ADP-
ribose) polymerase (PARP). Using a dual approach of PARP-1 suppression, by genetic
deletion or pharmacological inhibition with the new potent phenanthridinone PARP inhibitor
PJ34 [the hydrochloride salt of N-(oxo-5, 6-dihydro-phenanthridin-2-yl)-N, N-
dimethylacetamide], we studied whether the impaired cardiac function in endotoxic shock is …
during circulatory shock. Oxidant-induced cell injury involves the activation of poly (ADP-
ribose) polymerase (PARP). Using a dual approach of PARP-1 suppression, by genetic
deletion or pharmacological inhibition with the new potent phenanthridinone PARP inhibitor
PJ34 [the hydrochloride salt of N-(oxo-5, 6-dihydro-phenanthridin-2-yl)-N, N-
dimethylacetamide], we studied whether the impaired cardiac function in endotoxic shock is …
[PDF][PDF] Role of poly (ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents
L Pappc, C Szabo - Biochemical Pharmacology, 1785 - academia.edu
Reactive oxygen and nitrogen species are overproduced in the cardiovascular system
during circulatory shock. Oxidant-induced cell injury involves the activation of poly (ADP-
ribose) polymerase (PARP). Using a dual approach of PARP-1 suppression, by genetic
deletion or pharmacological inhibition with the new potent phenanthridinone PARP inhibitor
PJ34 [the hydrochloride salt of N-(oxo-5, 6-dihydrophenanthridin-2-yl)-N, N-
dimethylacetamide], we studied whether the impaired cardiac function in endotoxic shock is …
during circulatory shock. Oxidant-induced cell injury involves the activation of poly (ADP-
ribose) polymerase (PARP). Using a dual approach of PARP-1 suppression, by genetic
deletion or pharmacological inhibition with the new potent phenanthridinone PARP inhibitor
PJ34 [the hydrochloride salt of N-(oxo-5, 6-dihydrophenanthridin-2-yl)-N, N-
dimethylacetamide], we studied whether the impaired cardiac function in endotoxic shock is …
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