Role of promyelocytic leukemia zinc finger (PLZF) in cell proliferation and cyclin-dependent kinase inhibitor 1A (p21WAF/CDKN1A) gene repression
Promyelocytic leukemia zinc finger (PLZF) is a transcription repressor that was initially
isolated as a fusion protein with retinoic acid receptor α. PLZF is aberrantly overexpressed in
various human solid tumors, such as clear cell renal carcinoma, glioblastoma, and
seminoma. PLZF causes cellular transformation of NIH3T3 cells and increases cell
proliferation in several cell types. PLZF also increases tumor growth in the mouse xenograft
tumor model. PLZF may stimulate cell proliferation by controlling expression of the genes of …
isolated as a fusion protein with retinoic acid receptor α. PLZF is aberrantly overexpressed in
various human solid tumors, such as clear cell renal carcinoma, glioblastoma, and
seminoma. PLZF causes cellular transformation of NIH3T3 cells and increases cell
proliferation in several cell types. PLZF also increases tumor growth in the mouse xenograft
tumor model. PLZF may stimulate cell proliferation by controlling expression of the genes of …
以上显示的是最相近的搜索结果。 查看全部搜索结果