Role of the 52 KDa thioredoxin protein disulfide isomerase of Toxoplasma gondii during infection to human cells
Toxoplasma protein disulfide isomerase (PDI) is a 52 KDa thioredoxin of interest because
have a great immunogenicity for humans. We cloned and produced a recombinant protein
(recTgPDI) used to test its effect during infection to different human cell lines (epithelial and
retinal). We also determine if there were differences in gen expression during in vitro
infection. Expression of the gen was lower after entry into the host cells. PDI's inhibitors
bacitracin and nitroblue tetrazolium reduced the percent of infected cells and small amounts …
have a great immunogenicity for humans. We cloned and produced a recombinant protein
(recTgPDI) used to test its effect during infection to different human cell lines (epithelial and
retinal). We also determine if there were differences in gen expression during in vitro
infection. Expression of the gen was lower after entry into the host cells. PDI's inhibitors
bacitracin and nitroblue tetrazolium reduced the percent of infected cells and small amounts …
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