Roles of HMGA proteins in cancer

A Fusco, M Fedele - Nature Reviews Cancer, 2007 - nature.com
HMGA overexpression is a feature of malignant tumours and is also causally related to
neoplastic cell transformation. Here, we focus on the role of the HMGA proteinsHMGA proteins. …

Critical role of HMGA proteins in cancer cell chemoresistance

D D'Angelo, P Mussnich, C Arra, S Battista… - Journal of Molecular …, 2017 - Springer
… Here, we highlight the main studies evidencing a critical role of HMGA in … of cancer
cells to antineoplastic agents. Therefore, these studies account for the association of HMGA

The HMGA proteins: a myriad of functions

I Cleynen, WJM Van de Ven - … journal of oncology, 2008 - spandidos-publications.com
HMGA2 overexpression also has a causal role in inducing … full length HMGA proteins in
different tumors, the HMGA genes … the nuclear functions and regulation of the HMGA genes and …

Molecular biology of HMGA proteins: hubs of nuclear function

R Reeves - Gene, 2001 - Elsevier
HMGA protein levels are among the most consistent feature observed in all types of cancers
… The intrinsic attributes that endow the HMGA proteins with these remarkable abilities are a …

High Mobility Group A (HMGA) proteins: Molecular instigators of breast cancer onset and progression

R Sgarra, S Pegoraro, G Ros, C Penzo… - … )-Reviews on Cancer, 2018 - Elsevier
… Although this review focuses on the role of HMGA in BC, in order to provide a complete
overview about the influence of HMGA proteins on cancer hallmarks, it cannot be omitted to …

HMGA2 as a critical regulator in cancer development

B Mansoori, A Mohammadi, HJ Ditzel, PHG Duijf… - Genes, 2021 - mdpi.com
… In this review, we discuss these oncogenic roles of HMGA2 in different types of cancers
and propose that HMGA2 may be used for cancer diagnostic, prognostic, and therapeutic …

HMGA and cancer: a review on patent literatures

M De Martino, A Fusco… - … Patents on Anti-Cancer …, 2019 - ingentaconnect.com
… Here, we review the function of the HMGA proteins in … HMGA proteins. Objective: Current
review was conducted to check the involvement of HMGA as a druggable target in cancer

HMGA genes and proteins in development and evolution

R Vignali, S Marracci - International journal of molecular sciences, 2020 - mdpi.com
… In this review, we will mainly focus on the function of HMGA genes in physiological conditions,
and often refer to data obtained in studies of cancer or other pathologies inasmuch they …

High-mobility group A (HMGA) proteins and breast cancer

S Peluso, G Chiappetta - Breast Care, 2010 - karger.com
… This alternative splicing results in a frame shift so that the two proteins are identical … HMGA2
gene code for the full-length HMGA2 protein. As previously told, HMGA proteins have roles

HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents

D Palmieri, T Valentino, D D'angelo, I De Martino… - Oncogene, 2011 - nature.com
… Our results also indicate a key role for HMGA proteins in the cellular DDR. In fact, Hmga1/2
DKO MEFs repair DNA less efficiently than wild-type MEFs following IR exposure. Moreover, …