[PDF][PDF] Roles of magnesium ion in vascular relaxation via calcium channel and cyclooxygenase pathway in isolated rat aorta
ZANCO Journal of Pure and Applied Sciences, 2017•researchgate.net
The impact of Magnesium on vascular tone is mainly due to its calcium antagonist activity
resulting in smooth muscle relaxation. The present study was designed to determine the
roles of nitric oxide and calcium ions in magnesium-induced vasorelaxation in rats aortic
rings through these enzyme pathways. In this study, the aorta contracted with NE (3x10-6M),
pre-incubated with cyclooxygenase (COX) and epoxygenase inhibitors, then dose response
curve (DRC) made to magnesium sulfate (MgSO4) served as a control. On the other hand …
resulting in smooth muscle relaxation. The present study was designed to determine the
roles of nitric oxide and calcium ions in magnesium-induced vasorelaxation in rats aortic
rings through these enzyme pathways. In this study, the aorta contracted with NE (3x10-6M),
pre-incubated with cyclooxygenase (COX) and epoxygenase inhibitors, then dose response
curve (DRC) made to magnesium sulfate (MgSO4) served as a control. On the other hand …
Abstract
The impact of Magnesium on vascular tone is mainly due to its calcium antagonist activity resulting in smooth muscle relaxation. The present study was designed to determine the roles of nitric oxide and calcium ions in magnesium-induced vasorelaxation in rats aortic rings through these enzyme pathways. In this study, the aorta contracted with NE (3x10-6M), pre-incubated with cyclooxygenase (COX) and epoxygenase inhibitors, then dose response curve (DRC) made to magnesium sulfate (MgSO4) served as a control. On the other hand, the aorta incubated with L-
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