SARS-CoV-2 infection: The role of cytokines in COVID-19 disease
VJ Costela-Ruiz, R Illescas-Montes… - Cytokine & growth factor …, 2020 - Elsevier
COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of
physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly
immunological in nature. In the most severe cases, the prognosis can be markedly
worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-
12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data
on alterations in the expression of different cytokines in patients with COVID-19 who require …
physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly
immunological in nature. In the most severe cases, the prognosis can be markedly
worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-
12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data
on alterations in the expression of different cytokines in patients with COVID-19 who require …
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