SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α
S Nemoto, MM Fergusson, T Finkel - Journal of Biological Chemistry, 2005 - ASBMB
In lower organisms, increased expression of the NAD-dependent deacetylase Sir2
augments lifespan. The mechanism through which this life extension is mediated remains
incompletely understood. Here we have examined the cellular effects of overexpression of
SIRT1, the closest mammalian ortholog of Sir2. In PC12 cells, increased expression of the
NAD-dependent deacetylase SIRT1 reduces cellular oxygen consumption by∼ 25%. We
further demonstrate that SIRT1 expression can alter the transcriptional activity of the …
augments lifespan. The mechanism through which this life extension is mediated remains
incompletely understood. Here we have examined the cellular effects of overexpression of
SIRT1, the closest mammalian ortholog of Sir2. In PC12 cells, increased expression of the
NAD-dependent deacetylase SIRT1 reduces cellular oxygen consumption by∼ 25%. We
further demonstrate that SIRT1 expression can alter the transcriptional activity of the …
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