SJL Mice Infected with Acanthamoeba castellanii Develop Central Nervous System Autoimmunity through the Generation of Cross-Reactive T Cells for Myelin …
C Massilamany, F Marciano-Cabral, B Rocha-Azevedo… - PloS one, 2014 - journals.plos.org
We recently reported that Acanthamoeba castellanii (ACA), an opportunistic pathogen of the
central nervous system (CNS) possesses mimicry epitopes for proteolipid protein (PLP) 139–
151 and myelin basic protein 89–101, and that the epitopes induce experimental
autoimmune encephalomyelitis (EAE) in SJL mice reminiscent of the diseases induced with
their corresponding cognate peptides. We now demonstrate that mice infected with ACA
also show the generation of cross-reactive T cells, predominantly for PLP 139–151, as …
central nervous system (CNS) possesses mimicry epitopes for proteolipid protein (PLP) 139–
151 and myelin basic protein 89–101, and that the epitopes induce experimental
autoimmune encephalomyelitis (EAE) in SJL mice reminiscent of the diseases induced with
their corresponding cognate peptides. We now demonstrate that mice infected with ACA
also show the generation of cross-reactive T cells, predominantly for PLP 139–151, as …
SJL Mice Infected with Acanthamoeba castellanii Develop Central Nervous System Autoimmunity through the Generation of Cross-Reactive T Cells for Myelin …
J Reddy, C Massilamany, F Marciano-Cabral… - 2014 - digitalcommons.unl.edu
We recently reported that Acanthamoeba castellanii (ACA), an opportunistic pathogen of the
central nervous system (CNS) possesses mimicry epitopes for proteolipid protein (PLP) 139–
151 and myelin basic protein 89–101, and that the epitopes induce experimental
autoimmune encephalomyelitis (EAE) in SJL mice reminiscent of the diseases induced with
their corresponding cognate peptides. We now demonstrate that mice infected with ACA
also show the generation of crossreactive T cells, predominantly for PLP 139–151, as …
central nervous system (CNS) possesses mimicry epitopes for proteolipid protein (PLP) 139–
151 and myelin basic protein 89–101, and that the epitopes induce experimental
autoimmune encephalomyelitis (EAE) in SJL mice reminiscent of the diseases induced with
their corresponding cognate peptides. We now demonstrate that mice infected with ACA
also show the generation of crossreactive T cells, predominantly for PLP 139–151, as …
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