Food insecurity is widespread among US college students. We examined the impact of participating in the Supplemental Nutrition Assistance Program (SNAP) on food security status among students at a large public university using a quasi-experimental study. Sequentially adjusted logistic regression models were used to assess the impact of SNAP participation on food insecurity. SNAP participants experienced a 63% decrease in food insecurity from baseline to six months (p < .05). Adjusted models found 89% (95% CI 0.25–0.98) lower odds of food insecurity among program participants. Strategies to increase SNAP use may decrease food insecurity and its associated consequences among college students.