We investigated the role of STAT4 in mediating Th1-inducing activity of a vaccine adjuvant
monophosphoryl lipid A (MPL-A) using the standard antigen ovalbumin (OVA) in STAT4KO
mice. Our results show that splenocytes from STAT4KO mice displayed lower OVA-specific T-
cell proliferation and IL-2 production compared with wild-type (WT) mice. Further, IFN-γ
production was diminished in STAT4KO-derived splenocytes but the levels of IL-12 and TNF …