pigmented macules on the face. Triple combination creams (TCC), commonly known as
kligman's formula, had been regarded as the mainstay of treatment for years. Topical
metformin was recently studied for its melanopenic effects and potential use in melasma.
Aim of the work This study aimed to evaluate the efficacy and safety of using 30% metformin
cream to that of triple combination creams (Kligman's formula) in treating melasma. Patients …
Background: Melasma is an acquired common pigmentary condition that mostly presents as
pigmented macules on the face. Triple combination creams (TCC), commonly known as
kligman's formula, had been regarded as the mainstay of treatment for years. Topical
metformin was recently studied for its melanopenic effects and potential use in melasma.
Aim of the work: This study aimed to evaluate the efficacy and safety of using 30% metformin
cream to that of triple combination creams (Kligman's formula) in treating melasma. Patients …