Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium …
A Vik, A James, LL Gundersen - Planta medica, 2007 - thieme-connect.com
A Vik, A James, LL Gundersen
Planta medica, 2007•thieme-connect.comSeveral terpenes as well as synthetic analogues were screened for activity against
Mycobacterium tuberculosis in vitro using the microplate alamar blue assay.
Geranylgeraniol (MIC 1.56 μg/mL) and geranylgeranyl acetate (MIC 3.13 μg/mL) were
identified as potent and selective inhibitors of M. tuberculosis.
Mycobacterium tuberculosis in vitro using the microplate alamar blue assay.
Geranylgeraniol (MIC 1.56 μg/mL) and geranylgeranyl acetate (MIC 3.13 μg/mL) were
identified as potent and selective inhibitors of M. tuberculosis.
Abstract
Several terpenes as well as synthetic analogues were screened for activity against Mycobacterium tuberculosis in vitro using the microplate alamar blue assay. Geranylgeraniol (MIC 1.56 μg/mL) and geranylgeranyl acetate (MIC 3.13 μg/mL) were identified as potent and selective inhibitors of M. tuberculosis.
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