Secreted enteric antimicrobial activity localises to the mucus surface layer

U Meyer-Hoffert, MW Hornef, B Henriques-Normark… - Gut, 2008 - gut.bmj.com
… We speculate that the antimicrobial activity limits growth of mucus-associated commensals
as well reduces the establishment of pathogens. A certain commensal community, however, …

Antimicrobial peptides and the enteric mucus layer act in concert to protect the intestinal mucosa

A Dupont, L Heinbockel, K Brandenburg… - Gut microbes, 2014 - Taylor & Francis
… possesses no detectable antimicrobial activity, was recently … the intestinal mucus layer after
being secreted by the epithelial cells.Citation 27 Finally, SIgA within the enteric mucus layer

Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide

A Dupont, Y Kaconis, I Yang, T Albers, S Woltemate… - Gut, 2015 - gut.bmj.com
… by Paneth cells and secreted into the intestinal lumen.16 ,33 … detected in vivo within the
intestinal mucus layer (figure 1A, B … promote the antibacterial activity in the intestinal mucus layer.…

Immunological aspects of intestinal mucus and mucins

MEV Johansson, GC Hansson - Nature Reviews Immunology, 2016 - nature.com
… and also against our own intestinal microbiota. The outermost of these is the secreted mucus,
which entraps bacteria and … The bactericidal activity is very prominent in the small intestinal

[HTML][HTML] Mucus architecture and near-surface swimming affect distinct Salmonella Typhimurium infection patterns along the murine intestinal tract

M Furter, ME Sellin, GC Hansson, WD Hardt - Cell reports, 2019 - cell.com
… , dense mucus fills only the bottom of the intestinal crypts, … Our findings highlight the importance
of mucus in intestinal … Tm also accumulated on top of the inner colon mucus layer in our …

Epithelial antimicrobial defence of the skin and intestine

RL Gallo, LV Hooper - Nature Reviews Immunology, 2012 - nature.com
… /or secretion of antimicrobial activities in the small intestinal crypt … intestinal surface shows
that the inner mucus layer remains relatively free of bacteria, whereas the outer mucus layer

Human colonic mucus is a reservoir for antimicrobial peptides

L Antoni, S Nuding, D Weller… - Journal of Crohn's …, 2013 - academic.oup.com
… in the large intestinal mucus layer. In the mouse small intestine it was recently suggested
that indeed the secreted antimicrobial activity localizes to the mucus surface layer. In this study, …

Fight them or feed them: how the intestinal mucus layer manages the gut microbiota

BO Schroeder - Gastroenterology report, 2019 - academic.oup.com
… mice differ from their conventional counterparts, secreted mucus was not analysed in this
study. … before mucus secretion suggests that not only bacterial degradation of specific mucus

[PDF][PDF] Meyer-Hoffert, U. et al. Secreted enteric antimicrobial activity localises to the mucus surface layer. Gut 57, 764-835

U Meyer-Hoffert, T Midtvedt, K Pütsep, M Andersson - academia.edu
… We speculate that the antimicrobial activity limits growth of mucus-associated commensals
as well reduces the establishment of pathogens. A certain commensal community, however, …

[PDF][PDF] Secreted enteric antimicrobial activity localises to

K Pütsep, M Andersson, U Meyer-Hoffert, MW Hornef… - Gut, 2008 - researchgate.net
… We speculate that the antimicrobial activity limits growth of mucus-associated commensals
as well reduces the establishment of pathogens. A certain commensal community, however, …