pH-sensitive peptide hydrogel for glucose-responsive insulin delivery

X Li, M Fu, J Wu, C Zhang, X Deng, A Dhinakar… - Acta biomaterialia, 2017 - Elsevier
… one of important options for self-regulated insulin delivery to treat diabetes, which has become
an … glucose-responsive insulin delivery system using a pH-sensitive peptide hydrogel as a …

Glucose-Responsive Self-Regulated Injectable Silk Fibroin Hydrogel for Controlled Insulin Delivery

B Maity, H Moorthy, T Govindaraju - ACS Applied Materials & …, 2023 - ACS Publications
… Pancreas-mimicking glucose-responsive insulin delivery systems … hydrogel platform based
on phenylboronic acid-functionalized natural silk fibroin protein for regulated insulin delivery. …

Advanced hydrogels for the controlled delivery of insulin

S Mansoor, PPD Kondiah, YE Choonara - Pharmaceutics, 2021 - mdpi.com
… as coupling agents, the hydrogel was synthesized for oral insulin administration. Cell studies
… As these peptide hydrogels effectively demonstrated control of blood glucose, they were …

Self-assembled peptide hydrogels for the treatment of diabetes and associated complications

VP Chavda, D Teli, PC Balar, M Davidson… - Colloids and Surfaces B …, 2024 - Elsevier
… inventiveness of peptide-based hydrogels to treat diabetes and associated complications. …
A closed-loop glucose-responsive insulin delivery system [49], using a pH-sensitive peptide

Glucose-responsive hydrogel enhances the preventive effect of insulin and liraglutide on diabetic nephropathy of rats

MQ Tong, LZ Luo, PP Xue, YH Han, LF Wang… - Acta Biomaterialia, 2021 - Elsevier
… The glucose-sensitive hydrogels have attracted great attention in the field of insulin
delivery to … a glucose-sensitive hydrogel for insulin delivery [12]. For example, glucose-responsive …

An injectable particle-hydrogel hybrid system for glucose-regulatory insulin delivery

F Zhao, D Wu, D Yao, R Guo, W Wang, A Dong… - Acta biomaterialia, 2017 - Elsevier
insulin hydrogel for glucose-regulated delivery of insulin based on a unique particle-hydrogel
hybrid system offers a promising strategy for long-acting and self-regulated insulin delivery

Self-regulated glycosylated insulin delivery

SW Kim, CM Paii, M Kimiko, LA Seminoff… - Journal of controlled …, 1990 - Elsevier
… [ 11 ], with immobilized enzyme in a hydrogel where the gluconic acid protonates amine …
It was demonstrated that the proposed concept for the delivery of insulin from a selfregulated

Intestinal-Target and Glucose-Responsive Smart Hydrogel toward Oral Delivery System of Drug with Improved Insulin Utilization

R Ying, W Wang, R Chen, R Zhou, X Mao - Biomacromolecules, 2024 - ACS Publications
… -response polymer hydrogel using carboxymethyl agarose … ) was developed as an insulin
delivery carrier, exhibiting excellent … insulin delivery methods, the hydrogel oral delivery system …

Glucose-responsive nanoparticles for rapid and extended self-regulated insulin delivery

LR Volpatti, MA Matranga, AB Cortinas, D Delcassian… - ACS …, 2019 - ACS Publications
… -responsive insulin delivery in vivo, we coformulate rapid-release and prolonged-release
acetalated dextran nanoparticles (Ac-dex NPs) encapsulating GOx, catalase, and insulin. We …

Chemically controlled closed-loop insulin delivery

V Ravaine, C Ancla, B Catargi - Journal of Controlled Release, 2008 - Elsevier
… Instead of a hydrogel, a gating membrane can be used to deliver insulin in a self-regulated
fashion. … The ideal vector would enable insulin delivery in a self-regulated and long acting but …