Shock/turbulent boundary-layer interactions (STBLI) with separation are ubiquitous in aerospace-transportation applications and detrimentally affect the aerodynamic performance and system integrity. We therefore aim to understand the effect of separation control with air-jet vortex generators (AJVGs) on STBLI over both rigid and compliant walls, with the ultimate goal to reduce structural vibrations induced by the low-frequency unsteadiness of the shock system. An experimental study of a 24◦ compression-ramp interaction at Mach 2.52 over rigid and flexible panels of varying aspect ratio, with and without the influence of an array of AJVGs was carried out. The flow topology, turbulence behavior in the interaction region, and panel-flutter behavior are presented and discussed.