We read with interest the article by C. Dimeglio and colleagues, in which the authors apply a mathematical model to conclude that a SARS-CoV-2 (Severe Acute Respiratory Sindrome Coronavirus 2) seroprevalence of at least 50% is required to avoid an infection rebound after removal of containment measures1. In our study we found that SARS-CoV-2 seroprevalence was dramatically lower than this threshold, even in an area of initially unrestricted viral circulation.
Italy was the first European country that suffered a wide spread of Coronavirus Disease 2019 (COVID-19), caused by a novel betacoronavirus which was first identified in China and denominated SARS-CoV-2 (Severe Acute Respiratory Sindrome Coronavirus 2), which caused hundreds of thousands of cases2. During the epidemic, testing was restricted to severely symptomatic cases. Consequently, the true extent of the SARS-CoV-2 infection remains unknown.