When an organism encounters a pathogen, the host innate immune system activates to
defend against pathogen colonization and toxic xenobiotics produced. C. elegans employ
multiple defense systems to ensure survival when exposed to Pseudomonas aeruginosa
including activation of the cytoprotective transcription factor SKN-1/NRF2. Although wildtype
C. elegans quickly learn to avoid pathogens, here we describe a peculiar apathy-like
behavior towards PA14 in animals with constitutive activation of SKN-1, whereby animals …

When an organism encounters a pathogen, the host innate immune system activates to
defend against pathogen colonization and toxic xenobiotics produced. In humans, nuclear
factor erythroid 2-related factor (Nrf2) is a critical regulator in innate immune responses
under stress; it regulates gene expression in response to the oxidative stress induced by
pathogens and is activated within innate immunity cells in response to pathogenic stress.
Caenorhabditis elegans activate defense responses to ensure survival upon exposure to …