Serum and cerebrospinal fluid light neurofilaments and antibodies against them in clinically isolated syndrome and multiple sclerosis
L Fialová, A Bartos, J Švarcová, D Zimova… - Journal of …, 2013 - Elsevier
A release of light neurofilament subunits (NFL) into cerebrospinal fluid (CSF) and serum in
multiple sclerosis (MS) may induce an immune response. We examined CSF and serum
NFL levels and IgG antibodies against NFL in 19 patients with a clinically isolated syndrome
(CIS) early converted into MS, 20 CIS-non-converters, 23 MS patients and 32 controls. CSF
NFL levels were significantly higher in all patient groups. The highest CSF or intrathecally
(IT) synthesized anti-NFL antibodies and CSF/serum ratios of anti-NFL antibodies were …
multiple sclerosis (MS) may induce an immune response. We examined CSF and serum
NFL levels and IgG antibodies against NFL in 19 patients with a clinically isolated syndrome
(CIS) early converted into MS, 20 CIS-non-converters, 23 MS patients and 32 controls. CSF
NFL levels were significantly higher in all patient groups. The highest CSF or intrathecally
(IT) synthesized anti-NFL antibodies and CSF/serum ratios of anti-NFL antibodies were …
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