An impressive array of antigene approaches has been developed for recognition of double
helical DNA over the past three decades; however, few have exploited the 'Watson–
Crick'base-pairing rules for establishing sequence-specific recognition. One approach
employs peptide nucleic acid as a molecular reagent and strand invasion as a binding
mode. However, even with integration of the latest conformationally-preorganized backbone
design, such an approach is generally confined to sub-physiological conditions due to the …

An impressive array of antigene approaches has been developed for recognition of double
helical DNA over the past three decades; however, few have exploited the 'Watson–
Crick'base-pairing rules for establishing sequence-specific recognition. One approach
employs peptide nucleic acid as a molecular reagent and strand invasion as a binding
mode. However, even with integration of the latest conformationally-preorganized backbone
design, such an approach is generally confined to sub-physiological conditions due to the …