Short homodimeric and heterodimeric coiled coils
H Dong, JD Hartgerink - Biomacromolecules, 2006 - ACS Publications
Biomacromolecules, 2006•ACS Publications
In this communication, we discuss the design, synthesis, and characterization of four
peptides which are able to self-assemble into five different homo-and heterodimeric α-
helical coiled coils based on the pH of their environment. These peptides are very short,
containing only 14 or 21 amino acids each, and illustrate the minimum requirements
necessary to form dimeric coiled coils which are critical in a large number of biological and
materials design applications.
peptides which are able to self-assemble into five different homo-and heterodimeric α-
helical coiled coils based on the pH of their environment. These peptides are very short,
containing only 14 or 21 amino acids each, and illustrate the minimum requirements
necessary to form dimeric coiled coils which are critical in a large number of biological and
materials design applications.
In this communication, we discuss the design, synthesis, and characterization of four peptides which are able to self-assemble into five different homo- and heterodimeric α-helical coiled coils based on the pH of their environment. These peptides are very short, containing only 14 or 21 amino acids each, and illustrate the minimum requirements necessary to form dimeric coiled coils which are critical in a large number of biological and materials design applications.
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