Neural excitotoxicity is a typical factor in the early phase pathogenesis of cerebral ischemia.
Its cellular and molecular mechanisms are still unclear and clinical approaches are still
lacking of promising therapies. We have examined the vulnerability of cortical neurons to
short-term ischemia in rats by simultaneously analyzing the activities of inhibitory and
principal neurons in brain slices. Our results demonstrate that short-term in vitro ischemia
permanently impairs the excitability of inhibitory neurons (IN) and synaptic transmission …