To estimate the impact of delayed care during the coronavirus disease 2019 (COVID-19) pandemic on the outcomes of patients with neovascular age-related macular degeneration (AMD).

Consecutive patients with diagnosis of neovascular AMD were consecutively enrolled between March 9, 2020, and June 12, 2020, (during and immediately after the Italian COVID-19 quarantine). During the inclusion (or pandemic) visit (V₀), patients received a complete ophthalmologic evaluation, including optical coherence tomography (OCT). Best-corrected visual acuity (BCVA) and OCT findings from the two preceding visits (V₋₁ and V₋₂) were compared with data at V₀.

One-hundred patients (112 eyes) were enrolled in this study. The time interval between following visits was 110.7 ± 37.5 days within V₀ and V₋₁ and 80.8 ± 39.7 days within V₋₁ and V₋₂, respectively (P < 0.0001). BCVA was statistically worse at the V₀ visit as compared with the immediately preceding (V₋₁) visit (0.50 ± 0.43 LogMAR and 0.45 ± 0.38 LogMAR at the V₀ and V₋₁ visits, respectively; P = 0.046). On structural OCT, 91 out of 112 (81.2%) neovascular AMD eyes displayed the evidence of exudative disease activity at the V₀ visit, while 77 (68.7%) eyes exhibited signs of exudation at the V₋₁ visit (P = 0.022). No differences in terms of BCVA and OCT findings were detected between the V₋₁ and V₋₂ visits. In multiple regression analysis, the difference in BCVA between V₀ and V₋₁ visits was significantly associated with the interval time within these two visits (P = 0.026).

The COVID-19 pandemic-related postponement in patient care proved to be significantly associated with worse short-term outcomes in these patients.