Signaling in the mammalian circadian clock: the NO/cGMP pathway
Mammalian circadian rhythms are generated by a hypothalamic suprachiasmatic nuclei
(SCN) clock. Light pulses synchronize body rhythms by inducing phase delays during the
early night and phase advances during the late night. Phosphorylation events are known to
be involved in circadian phase shifting, both for delays and advances. Pharmacological
inhibition of the cGMP-dependent kinase (cGK) or Ca2+/calmodulin-dependent kinase
(CaMK), or of neuronal nitric oxide synthase (nNOS) blocks the circadian responses to light …
(SCN) clock. Light pulses synchronize body rhythms by inducing phase delays during the
early night and phase advances during the late night. Phosphorylation events are known to
be involved in circadian phase shifting, both for delays and advances. Pharmacological
inhibition of the cGMP-dependent kinase (cGK) or Ca2+/calmodulin-dependent kinase
(CaMK), or of neuronal nitric oxide synthase (nNOS) blocks the circadian responses to light …
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