Asymmetric C–H amination via nitrene transfer is a powerful tool to prepare enantioenriched
amine precursors from abundant C–H bonds. Herein, we report a regio-and enantioselective
synthesis of γ-alkynyl γ-aminoalcohols via a silver-catalyzed propargylic C–H amination.
The protocol was enabled by a new bis (oxazoline)(BOX) ligand designed via a rapid
structure–activity relationship (SAR) analysis. The method utilizes accessible carbamate
esters bearing γ-propargylic C–H bonds and furnishes versatile products in good yields and …

Asymmetric C–H amination via nitrene transfer (NT) is a powerful tool for the preparation of
enantioenriched amine building blocks from abundant C–H bonds. Herein, we report a
highly regio-and enantioselective synthesis of-alkynyl-amino alcohol motifs via a silver-
catalyzed propargylic C–H amination. The protocol was enabled by development of a new
bis (oxazoline)(BOX) ligand through a rapid structure-activity relationship (SAR) analysis.
The method utilizes readily accessible carbamate ester substrates bearing-propargylic C …