Simultaneous determination of rifampicin, isoniazid, pyrazinamide and ethambutol in 4-FDC tablet by Raman spectroscopy associated to chemometric approach
Tuberculosis is mainly treated by fixed dose combination therapy containing mainly
rifampicin, isoniazid, pyrazinamide and ethambutol. The quality control of these drugs in
these formulations is very important because of high incidence of resistance to these drugs.
Most of the analytical methods developed for the quantification analyze these drugs
individually and they are laborious, costly, and time consuming. The present work aims at
developing an alternative analytical method addressing these limitations of the traditional …
rifampicin, isoniazid, pyrazinamide and ethambutol. The quality control of these drugs in
these formulations is very important because of high incidence of resistance to these drugs.
Most of the analytical methods developed for the quantification analyze these drugs
individually and they are laborious, costly, and time consuming. The present work aims at
developing an alternative analytical method addressing these limitations of the traditional …
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