Simultaneous microdialysis and amphetamine infusion in the nucleus accumbens and striatum of freely moving rats: increase in extracellular dopamine and serotonin
L Hernandez, F Lee, BG Hoebel - Brain research bulletin, 1987 - Elsevier
To test the effects of systemic and local amphetamine on dopamine and serotonin release in
freely moving rats, guide cannulas were implanted in the nucleus accumbens and ventral
striatum for removable 200 μ. microdialysis probes. Comparing 45 min samples before and
after IP amphetamine (2 mg/kg), dopamine (DA) in dialysate from the accumbens increased
from a baseline of 3 pg/20 μl to 11 pg/20 μl; whereas dopamine metabolites, DOPAC and
HVA decreased. This was probably due to block of DA reuptake and inhibition of …
freely moving rats, guide cannulas were implanted in the nucleus accumbens and ventral
striatum for removable 200 μ. microdialysis probes. Comparing 45 min samples before and
after IP amphetamine (2 mg/kg), dopamine (DA) in dialysate from the accumbens increased
from a baseline of 3 pg/20 μl to 11 pg/20 μl; whereas dopamine metabolites, DOPAC and
HVA decreased. This was probably due to block of DA reuptake and inhibition of …
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