Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer
The most common events in breast cancer (BC) involve chromosome arm losses and gains.
Here we describe identification of 1089 gene-centric common insertion sites (gCIS) from
transposon-based screens in 8 mouse models of BC. Some gCIS are driver-specific, others
driver non-specific, and still others associated with tumor histology. Processes affected by
driver-specific and histology-specific mutations include well-known cancer pathways. Driver
non-specific gCIS target the Mediator complex, Ca++ signaling, Cyclin D turnover, RNA …
Here we describe identification of 1089 gene-centric common insertion sites (gCIS) from
transposon-based screens in 8 mouse models of BC. Some gCIS are driver-specific, others
driver non-specific, and still others associated with tumor histology. Processes affected by
driver-specific and histology-specific mutations include well-known cancer pathways. Driver
non-specific gCIS target the Mediator complex, Ca++ signaling, Cyclin D turnover, RNA …
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