BACKGROUND: The immune system's role in ST-segment–elevated myocardial infarction
(STEMI) remains poorly characterized but is an important driver of recurrent cardiovascular
events. While anti-inflammatory drugs show promise in reducing recurrence risk, their broad
immune system impairment may induce severe side effects. To overcome these challenges,
a nuanced understanding of the immune response to STEMI is needed. METHODS: For this,
we compared peripheral blood mononuclear single-cell RNA-sequencing (scRNA-seq) and …

The role of the immune system during and in response to acute myocardial infarction (MI) is
poorly characterized but is an important driver of recurrent cardiovascular events.
Antiinflammatory drugs have shown promising effects on lowering this recurrency risk, but
broadly impair the immune system and may induce severe side effects. To overcome these
challenges a more detailed understanding of the immune response to myocardial infarction
is needed. For this, we compared peripheral blood mononuclear cell (PBMC) single-cell …