Single-Unit Imaging of Membrane Protein- Embedded Nanodiscs from Two Oriented Sides by
Resource Single-Unit Imaging of Membrane Protein-Embedded Nanodiscs from Two Oriented
Sides by High-Speed Atomic Force Microscopy | CiNii Research … Single-Unit Imaging of
Membrane Protein- Embedded Nanodiscs from Two Oriented Sides by Resource Single-Unit
Imaging of Membrane Protein-Embedded Nanodiscs from Two Oriented Sides by High-Speed
Atomic Force Microscopy … Single-Unit Imaging of Membrane Protein-Embedded …

Membrane proteins play important roles in various cellular functions. To analyze membrane
proteins, nanodisc technology using membrane scaffold proteins allows single membrane
protein units to be embedded into the lipid bilayer disc without detergents. Recent
advancements in high-speed atomic force microscopy (HS-AFM) have enabled us to monitor
the real-time dynamics of proteins in solution at the nanometer scale. In this study, we report
HS-AFM imaging of membrane proteins reconstituted into nanodiscs using two membrane …