Sinonasal delivery of resveratrol via mucoadhesive nanostructured microparticles in a nasal polyp mouse model
Resveratrol (RSV) has been shown to effectively suppress chronic rhinosinusitis with nasal
polyps in a mouse model; however, when locally administered to the sinonasal cavity, bolus
RSV is limited by low drug bioavailability owing to its low aqueous solubility and relatively
rapid clearance from the administration site. To address this limitation, we propose
mucoadhesive nanostructured microparticles (PLGA/PEG NM) as a potential carrier for the
sinonasal delivery of RSV. In this study, PLGA/PEG NM released RSV in a sustained …
polyps in a mouse model; however, when locally administered to the sinonasal cavity, bolus
RSV is limited by low drug bioavailability owing to its low aqueous solubility and relatively
rapid clearance from the administration site. To address this limitation, we propose
mucoadhesive nanostructured microparticles (PLGA/PEG NM) as a potential carrier for the
sinonasal delivery of RSV. In this study, PLGA/PEG NM released RSV in a sustained …
Sinonasal delivery of resveratrol via mucoadhesive nanostructured microparticles in a nasal polyp mouse model.
LMY Lee MingYu, PCG Park ChunGwon… - 2017 - cabidigitallibrary.org
Resveratrol (RSV) has been shown to effectively suppress chronic rhinosinusitis with nasal
polyps in a mouse model; however, when locally administered to the sinonasal cavity, bolus
RSV is limited by low drug bioavailability owing to its low aqueous solubility and relatively
rapid clearance from the administration site. To address this limitation, we propose
mucoadhesive nanostructured microparticles (PLGA/PEG NM) as a potential carrier for the
sinonasal delivery of RSV. In this study, PLGA/PEG NM released RSV in a sustained …
polyps in a mouse model; however, when locally administered to the sinonasal cavity, bolus
RSV is limited by low drug bioavailability owing to its low aqueous solubility and relatively
rapid clearance from the administration site. To address this limitation, we propose
mucoadhesive nanostructured microparticles (PLGA/PEG NM) as a potential carrier for the
sinonasal delivery of RSV. In this study, PLGA/PEG NM released RSV in a sustained …