Six3 and Six6 are two genes required for the specification and proliferation of the eye field in
vertebrate embryos, suggesting that they might be the functional counterparts of the
Drosophila gene sine oculis (so). Phylogenetic and functional analysis have however
challenged this idea, raising the possibility that the molecular network in which Six3 and
Six6 act may be different from that described for SO. To address this, we have performed
yeast two-hybrid screens, using either Six3 or Six6 as a bait. In this paper, we report the …