The evidence linking sleep-disordered breathing to increased mortality and cardiovascular
morbidity has been conflicting and inconclusive. We hypothesized that a potential adverse
effect of disordered breathing would be more obvious in patients with established vascular
disease. In a prospective cohort study 408 patients aged 70 yr or younger with verified
coronary disease were followed for a median period of 5.1 yr. An apnea–hypopnea index
(AHI) of⩾ 10 and an oxygen desaturation index (ODI) of⩾ 5 were used as the diagnostic …

Coronary artery disease (CAD) is one of the most frequent diseases in industrial nations.
Despite significant advances in diagnosis and therapy, CAD and its long-term
consequences are important contributors to morbidity and mortality. Therefore, in addition to
management of traditional CAD risk factors, there are continued efforts to evaluate other
factors and comorbidities that might contribute to the development and progression of CAD.
One such factor is sleep-disordered breathing (SDB), which is characterized by repetitive …