This paper to analyze the effect of nomophobia on powerlessness, meaninglessness, normlessness, social isolation, and self-estrangement of students in Palembang. The method used is a survey with a cross-sectional study approach. The sample of this study were students of Junior High School, Senior High School, and College in Palembang, aged 12-21 years as many as 241 students. The sampling technique used is multistage random sampling. Test analysis carried out by Manova test. The results showed that all samples were student nomophobia, even 68.1% at a moderate level, and 51.9% had relatively high levels of social alienation. This nomophobia has a significant effect on simultaneous with a P-value< 0.05. The influence of nomophobia on powerlessness, meaninglessness, normlessness, social isolation, or self-estrangement each have P-value< 0.05, so that is significant. However, there is a difference between nomophobia mild and moderate or vice versa, both based on powerlessness, meaninglessness, normlessness, social isolation, and self-estrangement. The tendency is that students have experienced social alienation so that early prevention efforts are needed. This effort can make with community-based social learning.