Soft colloidal particles with multiple surface patches of differing composition are critical to the
development of complex macroscopic structures that can serve as interfacial catalysts,
macroscale surfactants, electronically responsive materials, and drug delivery vehicles.
Here, we present a continuous process for the scalable formation of soft colloidal particles
with multiple surface domains that employs well-established principles of polymer
precipitation and phase separation to controllably shape particle architectures. Our results …