[HTML][HTML] Solutions to the discrepancies in the extent of liver damage following ischemia/reperfusion in standard mouse models

RF van Golen, MJ Reiniers, M Heger… - Journal of …, 2015 - journal-of-hepatology.eu
Due to their experimental versatility, mouse models are commonly used to study hepatic
ischemia/reperfusion (I/R) injury in relation to (I) the efficacy of surgical interventions [1],(II)
the pathophysiological role of biomolecules [2] as well as cells [3], and (III) the interplay with
parenchymal liver disease [4]. For the assessment of post-ischemic liver damage, plasma
alanine transaminase (ALT) and the extent of necrotic cell death, determined by routine
clinical chemistry and histology, respectively, are commonly used as gold standard …
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