Solvent-free synthesis of substituted thiopyrans via multicomponent reactions of α-haloketones
F Sheikholeslami-Farahani, Z Hossaini… - Chinese Chemical …, 2014 - Elsevier
Chinese Chemical Letters, 2014•Elsevier
A straightforward and efficient method for the synthesis of thiopyran derivatives via three-
component reaction of alkyl propiolate, benzoylisothiocyanate or its derivatives and α-
haloketones in the presence of triphenylphosphine under solvent-free conditions at 70° C
without using any catalyst is reported. The method offers several advantages including high
yields of products and an easy work-up procedure.
component reaction of alkyl propiolate, benzoylisothiocyanate or its derivatives and α-
haloketones in the presence of triphenylphosphine under solvent-free conditions at 70° C
without using any catalyst is reported. The method offers several advantages including high
yields of products and an easy work-up procedure.
Abstract
A straightforward and efficient method for the synthesis of thiopyran derivatives via three-component reaction of alkyl propiolate, benzoylisothiocyanate or its derivatives and α-haloketones in the presence of triphenylphosphine under solvent-free conditions at 70 °C without using any catalyst is reported. The method offers several advantages including high yields of products and an easy work-up procedure.
Elsevier
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