SopE acts as an Rab5-specific nucleotide exchange factor and recruits non-prenylated Rab5 on Salmonella-containing phagosomes to promote fusion with early …
Rab-GTPase regulates the fusion between two specific vesicles. It is well documented that,
for their biological function, Rab proteins need to be prenylated for attachment to the vesicle
membrane. In contrast, we showed in the present investigation that SopE, a type III secretory
protein of Salmonella, translocates onto Salmonella-containing phagosomes (LSP) and
mediates the recruitment of non-prenylated Rab5 (Rab5: ΔC4) on LSP in GTP form.
Simultaneously, SopE present in infected cell cytosol acts as an Rab5-specific exchange …
for their biological function, Rab proteins need to be prenylated for attachment to the vesicle
membrane. In contrast, we showed in the present investigation that SopE, a type III secretory
protein of Salmonella, translocates onto Salmonella-containing phagosomes (LSP) and
mediates the recruitment of non-prenylated Rab5 (Rab5: ΔC4) on LSP in GTP form.
Simultaneously, SopE present in infected cell cytosol acts as an Rab5-specific exchange …
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