We investigated the spatiotemporal distribution and sources of cellular oxidative potential
(OP) in the Midwest US. Weekly samples were collected from three urban [Chicago (IL),
Indianapolis (IN), and St. Louis (MO)], one rural [Bondville (IL], and one roadside site
[Champaign (IL)] for a year (May 2018 to May 2019), and analyzed for water-soluble cellular
OP using a macrophage reactive oxygen species (ROS) assay. Chemical composition of the
samples including several carbonaceous components, inorganic ions, and water-soluble …

Ambient fine particulate matter (PM 2.5) is associated with numerous health complications,
yet the specific PM 2.5 chemical components and their emission sources contributing to
these health outcomes are understudied. Our study analyzes the chemical composition of
PM 2.5 collected from five distinct locations at urban, roadside and rural environments in
midwestern region of the United States, and associates them with five acellular oxidative
potential (OP) endpoints of water-soluble PM 2.5. Redox-active metals (ie, Cu, Fe, and Mn) …