Src family kinases are involved in the differential signaling from two splice forms of c-Kit
O Voytyuk, J Lennartsson, A Mogi, G Caruana… - Journal of Biological …, 2003 - ASBMB
In both mice and humans alternate splicing results in isoforms of c-Kit characterized by the
presence or the absence of a tetrapeptide sequence, GNNK, in the juxtamembrane region of
the extracellular domain. Dramatic differences in the kinetics and magnitude of activation of
the intrinsic tyrosine kinase activity of c-Kit between the GNNK− and GNNK+ isoforms has
previously been shown. Here we report the analysis of downstream targets of receptor
signaling, which revealed that the signaling was differentially regulated in the two splice …
presence or the absence of a tetrapeptide sequence, GNNK, in the juxtamembrane region of
the extracellular domain. Dramatic differences in the kinetics and magnitude of activation of
the intrinsic tyrosine kinase activity of c-Kit between the GNNK− and GNNK+ isoforms has
previously been shown. Here we report the analysis of downstream targets of receptor
signaling, which revealed that the signaling was differentially regulated in the two splice …